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Schizophrenia

" Suspicious and frightened, the victim fears he can trust neither his own senses, nor the motives of other people…his skin prickles, his head seems to hum, and 'voices' annoy him. Unpleasant odors choke him, bright and colorful vision pass before his eyes. When someone talks to him, he hears only disconnected words. When he tries to speak, his own words sound foreign to him."

(Yolles, 1967)

Schizophrenia is a disturbance of form and content of thought. It affects the mood of the person and the sense of self in relationship to the external world. The behavior of schizophrenics may be apparently purposeless. They distort reality, and withdraw from the society. They have a disorganized and fragmented perception, thought and emotion. Often schizophrenia develops slowly and insidiously. The early clinical picture may be dominated by seclusiveness, gradual lack of interest in the surrounding world, excessive daydreaming, blunting of affect, and mildly inappropriate responses.

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Causes of Schizophrenia
There is no conclusive evidence for the causes of Schizophrenia. There are various theories to explain the development of this disorder.

Biological factors:Biological factors include heredity, biochemical factors and neurophysiological factors.
Genetic factors play an important causal role. It has been found that the incidence of schizophrenia among children of schizophrenic parent/s is very high.

The presence of some chemical agents in the bloodstream, even in minute amounts, can produce profound mental changes. Lysergic acid (LSD) and mescaline can lead to a temporary disorganization of thought processes.
Neurophysiological factors are due to abnormalities of brain chemistry.

Psychological factors: Psychic trauma, pathogenic parent child and family interactions, destructive marital interactions, pseudo mutuality - where family relationships often had the appearance of being mutual, understanding and open, but in fact were not - and role inflexibility, that is, rigid and depersonalized family role structure. Others include faulty communications between parent and child, faulty learning and coping, deficient self-structure and exaggerated use of ego defense mechanisms.

Sociological factors: Though disorder of thought and emotion are common, cultural factors also influence the type and symptom content of schizophrenic disorders that occur. Defeat in close interpersonal relationships and split between an individual’s false outer self and his true inner self results in psychotic breakdown, which usually takes the form of schizophrenia.

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Types of Schizophrenia
Acute type: Acute schizophrenia may be found suddenly in a person whose behavior was previously relatively normal. Here the individuals feel perplexed, confused, depressed, suffer emotional turmoil, and undergo delusions of reference and excitement. They have a dreamlike dissociation, and sometimes are fearful, experiencing qualities of nightmare. Individuals seem to undergo massive breakdown of filtering processes. Though the individuals do not remain in the state of acute schizophrenia for a sustained period and recover within few months, such episodes keep on recurring.

Paranoid type: Paranoid patients show a history of severe suspiciousness and difficulties in interpersonal relationships. The attention that they receive prompts them to develop delusions of grandeur and makes them believe that they are extraordinary beings. They experience delusions and hallucinations and are impaired of critical judgement. They behave in an erratic, unpredictable and sometimes dangerous manner.

Catatonic type: Individuals having psychomotor disturbances with extreme withdrawal or extreme excitement symptoms are said to have catatonic schizophrenia. In withdrawal reaction the individuals may sit motionless for hours or even days in a stereotyped position. Any efforts to change their position are confronted with stubborn resistance. In extreme excitement reaction the individuals may talk or shout suddenly incoherently, pace rapidly, and engage in uninhibited, impulsive, and frenzied behavior. In this state, the individual may be dangerous. Some catatonic patients are very suggestible and obey commands or repeat the actions of others (echopraxia) or repeat the words in a particular way (echolalia).

Disorganized or hebephrenic type: Occurring at an early age, hebephrenic reaction represents severe disintegration of personality. They have loose associations and are frequently incoherent. Their emotional experience is shallow and is characterized by inappropriate laughter, silliness, and peculiar mannerisms.

Simple Type: Simple schizophrenia is often found to begin in early adolescence. Individuals having simple schizophrenia are insidiously depleted of thought, affect and behavior. Their interest in external activities, interests and attachments progressively decreases and they tend to withdraw from social relationships.

Childhood Schizophrenia: Preoccupation with fantasy, and markedly atypical and withdrawn behavior prior to puberty is common. The individuals are immature, withdrawn, and fail to develop an identity separate from mother. There may be symptoms of autism (dominated with subjective self-centered thoughts).

Chronic undifferentiated type: Though chronic undifferentiated schizophrenia definitely has symptoms in thought, affect, and behavior, it cannot be classified under one of the other types (mentioned above).

Latent type: Individuals have various symptoms of schizophrenia but lack a history of full-blown schizophrenic episode.

Residual type: Individuals in remission following a schizophrenic episode show mild indications of schizophrenia.

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Symptoms
Breakdown of perpetual filtering
By means of complex processes of filtering, individuals can selectively attend to and cope with the great mass of incoming sensory information to which they are exposed. In this way they perceive their world in an orderly and meaningful way. Schizophrenics, by contrast, are apparently unable to screen out distractions or to discriminate between relevant and irrelevant input. They are highly sensitive to stimuli of all kinds- from both internal and external sources- and are unable to integrate their perceptions into a meaningful pattern.

Disorganization of thought and emotion
Schizophrenics have difficulty in concentrating, impaired ability to sort relevant from irrelevant stimuli and to maintain order in the association of thoughts, and a marked reduction in problem-solving and decision-making ability. Since emotions are strongly influenced by cognitive processes it is not surprising that the disorganization of thought is accompanied by distortions in affective responses.

Anxiety and panic
Individuals experience loss of control over their thoughts and feelings in the intense anxiety and panic that characterize the acute schizophrenic reaction.This happens when the individuals cannot filter incoming stimuli and attend selectively, when they are plagued by racing thoughts or are 'locked in' on a particular theme, and when their thoughts don't line up with their feelings. Not only does the disorganization of thought and emotion involve the environment, it involves the self structure as well. The self, which normally functions as the integrating core of the personality, become diffused, fragmented, and chaotic. Individuals may experience varying degree of confusion concerning who and what they are, accompanied by some measure of depersonalization. The loss of control over their thoughts and feelings combined with the fragmentation of the self and a sense of depersonalization adds up to acute panic.

Delusions and hallucinations
For many schizophrenics the inner turmoil and anxiety are accompanied by delusions - beliefs maintained despite their logical absurdity or objective evidence showing they lack any foundation in reality. The Schizophrenics may also evidence hallucinations- the perception of objects and events without any appropriate stimuli. Thus they may hear voices telling them what to do or commenting on or criticizing their actions. In some instances the voices are ascribed to relative or friends, in others to 'enemies', and in still other cases the messages received "from God" or from some organization and tell them of great powers that have been conferred on them or of their mission to save humanity.

Auditory hallucinations are the most common, visual and other sensory modalities are also involved. Schizophrenics may see angels in heaven or some noxious gas that has been injected into their room, or taste poison in their food. As in the case of delusions, the disorganization and fragmentation of thoughts and experience distort their evaluations of stimuli.

Withdrawal of reality
In acute Schizophrenic episodes, individuals tend to withdraw temporarily from interaction with others and become preoccupied with their own inner world of experiencing. In chronic cases, the withdrawal tends to be more enduring. Individuals withdraw themselves from the aversive external world into their own private world.
This leads to a loss of interest in people and events in the 'real' world. Efforts to lead or force the patient back into the world of reality may arouse negativistic and hostile behavior.

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Treatment
Until recent times, a number of medications have been brought in to reduce the biochemical imbalances close to normal. Antipsychotic medications are very effective in the treatment of delusions and hallucinations. These include antianxiety drugs or minor tranquilizers to decrease apprehension, antidepressants to elevate mood, major tranquilizers to control thought disorders. Though these drugs are effective in the treatment and are used in combination with each other, they cause a wide range of side effects - constipation, dry mouth, weight gain, lethargy, restlessness, impotence, menstrual irregularities, cramps, dizziness, and stiffness of the limbs.These side effects can be corrected by altering the dosage or by other medications- psychotherapy or a combination of chemotherapy and psychotherapy.

Psychotherapy is used to help individuals correct thought disorders, reestablish bonds with reality, and eliminate specific psychotic symptoms. Behavioral techniques are used to help individuals learn behavior that lead to social acceptance. In severe and chronic cases, hospitalization is often required to prevent self-inflicted harm or harm to others, and to provide for the patient's basic needs of food, rest, and hygiene. They are taken care of and helped to meet the challenges of daily life and get along with others.

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